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KMID : 0624620230560020049
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BMB Reports
2023 Volume.56 No. 2 p.49 ~ p.55
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The role of tRNA-derived small RNAs in aging
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Ha Seokjun G.
Lee Seung Jae V.
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Abstract
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Aging is characterized by a gradual decline in biological functions, leading to the increased probability of diseases and deaths in organisms. Previous studies have identified biological factors that modulate aging and lifespan, including non-coding RNAs (ncRNAs). Here, we review the relationship between aging and tRNA-derived small RNAs (tsRNAs), ncRNAs that are generated from the cleavage of tRNAs. We describe age-dependent changes in tsRNA levels and their functions in age-related diseases, such as cancer and neurodegenerative diseases. We also discuss the association of tsRNAs with aging-regulating processes, including mitochondrial respiration and reduced mRNA translation. We cover recent findings regarding the potential roles of tsRNAs in cellular senescence, a major cause of organismal aging. Overall, our review will provide useful information for understanding the roles of tsRNAs in aging and age-associated diseases.
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KEYWORD
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Aging, Longevity, Non-coding RNA, Senescence, Small RNA
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